BCMB20002 Lecture 2: Summary Notes
9 Mar 2017
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Must know the structures of 20 amino acids, both physical properties and active properties. Draw, recognize, full name, 3-letter and 1-letter code. Molecular structure: generic and side chains functional properties. Primary sequence the covalent structure of proteins: the peptide bonds. Secondary structure the ramachandran plot ( , ) -helix and -sheets, and -turns. Keeping a protein together non-covalent interactions, hydrogen bond, van der waal contacts. Tertiary structure limited number of ways a protein can fold. Quaternary structure how many 3o structures come together. Human genome consists of 3. 2 x 109 bases, but only 25,000 genes. Only 1. 5% of the genome codes for proteins (~98% junk dna is important for regulation). Myoglobin was the first structure find in 1960. Nucleic acid bases are for dna and rna. Although the same sequence can fold into misfolded protein structures, however they are in a stable state. These carry out every metabolic process in the body. One gene can code for several protein products.
