BCMB30004 Lecture Notes - Lecture 9: Arginine, Cytosol, Microtubule
Document Summary
The three types of second messenger generating events and how they contribute to cell growth and proliferation: * event 1: relates to the generation of calcium and the activation of a tumour promoting protein kinase c/pkc. * event 2: the generation of the phospholipid second messengers and also activating the pro- survival and pro-proliferation kinases pkb & pdk1. It was found that some of the serine/threonine kinases are substrates for tyrosine kinase and so when tyrosine kinase phosphorylates the serine/threonine kinase it becomes activated and then it can mediate cell growth & proliferation. * one of the effectors of ras is a protein serine/threonine kinase raf-1. The researchers were searching for how egf stimulated cell growth proliferation and so they were looking for substrates for egf receptors. One of the substrates identified was the receptor itself because it undergoes a trans-autophosphorylation reaction.