BIOL30001 Lecture Notes - Lecture 8: Dyspareunia, Activin And Inhibin, Osteoclast
17 Aug 2018
School
Department
Course
Professor
Document Summary
Menopause: what and when: the menopause is the nal menstrual period, average age of menopause around 51-52 years (age range 48-55 years, de ned retrospectively after 12 months of absent periods. Perimenopause, menopause transition, climacteric: the period when ovarian function declines, cycles are irregular and menopausal symptoms appear, begins mid to late 40s, ends one year after menopause. Post menopause: the whole lifetime after menopause, no periods, no ovulations, steroid hormones low, cannot conceive. Early menopause: 40-45 years, 5-8% of women (mishra et al. , 2017 human reprod) Premature ovarian insu ciency (poi), premature menopause: menopause prior to 40 years old, 2% of women (mishra et al. , 2017 human reprod) May have intermittent ovarian activity, pregnancy rate 5-50% in lifetime. Increased life expectancy from ~42 to ~85 in 100 yrs, with 95% women now reaching menopause. Age of menopause hasn"t really changed much, but life expectancy has drastically increased. Factors regulating the age at natural menopause are poorly understood/ controversial.
