BIOM20001 Lecture Notes - Lecture 47: Cell Wall, Peptidoglycan, Aureus
Document Summary
Came from streptomyces (gpr from soil) - now use gentamicin. Recognition phase of protein synthesis: anti-codon on trna recognise codon on mrna. Binding site involves rrna and proteins - binds quite tightly. It makes the codon look different (translated into an abnormal protein so vital functions or membranes might not form properly so bacteria cells die) or look like a nonsense (stop) codon. This stuffs up protein synthesis including structural protein synthesis. Example of a terrible aminoglycoside with many places where bacterial enzymes can modify it and inactivate it. Bacteria have acetylating, adenylating, phosphorylating enzymes, used for their own metabolism and they can change their enzymes slightly to be able to act on aminoglycoside antibiotics as well. Only need to modify one site to inactivate gentamicin etc. Treats tb, usually serious gram negative infections (also treats gram positive and works well together with beta-lactams)
