BIOM20001 Lecture Notes - Lecture 48: Poliovirus, Reverse Transcriptase, Rna-Dependent Rna Polymerase
Document Summary
All assemble -> then either bud (if enveloped) or it builds up in the cell until the cell bursts and virus is released (e. g. pox) Binding to the receptor limits the cell type(s) and species that can be infected. If a cell doesn"t have the right receptor it can never be infected. Receptors can be proteins, glycoproteins, glycolipids, carbohydrates and other structures that perform normal functions of the cell and that the virus has evolved to use. Once the virus has entered the cell and the genome has been uncoated it has to go to the right place in the cell for replication. Usually this is the cytoplasm for rna viruses and the nucleus for dna viruses (exceptions: influenza rna but goes to nucleus, hiv is rna but goes to nucleus, poxvirus is a dna virus but goes to cytoplasm) Virus families have very different strategies for replication.
