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BIOM20001 Lecture Notes - Lecture 55: Cytokine, Cd86, Interleukin 10

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plumdeer622
6 Oct 2018
School
University of Melbourne
Department
Biomedicine
Course
BIOM20001
Professor
All

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Document Summary

Protein antigens may be processed (degraded into peptides) either in endosomes or in the cytosol. Endosomal processing results in presentation on class ii mhc molecules (for exogenous antigens that are phagocytosed into endosomes) Cytosolic processing results in presentation on class i mhc molecules (for endogenous or cytosolic antigens) Peptide mhc class i pathway: antigen degraded by proteasome. Peptides loaded to mhc i which are synthesised in er-->golgi-->pm. Peptide-mhc class ii pathway (apcs): antigen endocytosed-->degraded in endosome. Invariant (li) chains assembles with mhcii which blocks peptide binding site of mhc ii. This protects peptide binding cleft from cytosolic peptides. Invariant chain removed when vesicle merges with endosome. There is a possibility of cross presentation where exogenous antigens bind to mhc i. Antigen processing and presentation leads to peptides associated with the. T cells activation: when their tcr binds peptide antigens displayed on mhc molecules. The plus means positive (i. e. it is expressed)

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Related Questions

Immunology worksheet help?

1. In people infected with human cytomegalovirus, class I MHC andb2-microglobulin are produced, but very little mature class I MHCis found at the cell surface. Inhibition of which of the followingmolecules by human cytomegalovirus may account for thisphenomenon?
A. TAP
B. Ii
C. TCR
D. CLIP
E. RAG
2. Your chances of having the same MHC haplotype as your siblingare:
A. 1:2.
B. 1:4.
C. 1:16.
D. 1:8.
E. 1:1.
3. Which of the following is the BEST example of self-MHCrestriction of T cells?
A. A T-cell clone is deleted when it binds too tightly to selfMHC.
B. A T-cell clone responds more vigorously to a self-peptide thana foreign peptide.
C. A T-cell clone recognizes foreign MHC.
D. A T-cell clone only recognizes foreign peptides when presentedby self MHC.
E. All of the above
4. MHC molecules:
A. are conserved between individuals.
B. bind repeating patterns found on pathogens.
C. are recognized by T cells.
D. are membrane-bound molecules found exclusively on T cells.
E. are secreted by T cells and bind and neutralize antigen in theserum.
5. Tasmanian devils are a largely inbred population with littlediversity in the MHC. Which of the following would be a likelyoutcome of this?
A. They would compensate for low diversity in the MHC with highdiversity in the TCR.
B. They would compensate for low diversity in the MHC with highdiversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above
6. How many different MHC classical class I proteins does eachnucleated cell in a human heterozygous at the MHC locusexpress?
A. Six
B. Two
C. Three
D. One
E. None. Only APC express class I.
7. MHC polymorphisms tend to cluster:
A. in the peptide-binding groove.
B. in the transmembrane domain.
C. in the coreceptor contact residues.
D. in the framework region.
E. All of the above
8. A mutation that renders the MHC class II molecule DMnonfunctional would likely lead to:
A. cells with no class II MHC.
B. a deficiency in CD8+ T cells.
C. cells with class II MHC only bound with CLIP.
D. cells with class II MHC bound with a variety ofself-antigens.
E. cells with no DO.
9. The human MHC locus is one of the most polymorphic regions ofthe genome. What does this mean?
A. This region is regulated by many different mechanisms.
B. Sequence variability is low in this region.
C. There are many introns in this region.
D. There are many different alleles of these genes.
E. It has the most different genes.
10. Which of the following is an example ofcross-presentation?
A. An exogenous peptide being presented on MHC class II
B. A B-cell antigen being presented to a T cell
C. An endogenous peptide being presented on MHC class I
D. An endogenous peptide being presented on MHC class II
E. An exogenous peptide being presented on MHC class I