BIOM20001 Lecture Notes - Lecture 61: Lipoxin, Phagocyte, Microorganism
Document Summary
Leukocyte granules include bactericidal permeability increasing enzyme, a phospholipase that mediates membrane degradation (degrades phospholipids, particularly for multicellular organisms) Lysosomal acid hydrolases function at low ph in lysosome. Effector mechanisms do not distinguish between offender and host. Activated leukocytes may release toxic products into extracellular space. Regurgitation during feeding - bystander damage - sometimes regurgitate components of lysozome into extracellular space after phagocytosing a tissue. Frustrated phagocytosis: release toxic compounds/enzymes into extracellular space to break down large microorganisms that are too large to phagocytose. Ingestion of substance (urate crystals) damage phagolysosome which may release damaging enzymes. Inactivate precursors circulating in the plasma and activated at the site of inflammation. A larger no. of possible regulators can modulate the responses. Each step produces end products that can have different activities (due to breaking down of products, each fragment can do a different job)
