BIOM20002 Lecture Notes - Lecture 65: Proximal Tubule, Aquaporin 2, Cyclic Adenosine Monophosphate

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15 Sep 2018
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A negative water balance will be most obvious as: There is a reduction but not a large change. Reduction in volume is shared by all water both intracellular and extracellular. A very small decrease due to the small decrease in plasma volume. Detects stretch in cell anterior hypothalamus respond to changes in cell size, e. g. shrinking if negative water balance due to increase in. A negative water balance will normally result in: Vasopressin (antidiuretic hormone): diuresis = excretion of water. So acts against this to produce concentrated urine. If osmolarity goes up (increased ecf conc) then more vasopressin is released. Normal set point where some vasopressin is released at normal osmolarity. Lets the system go down as well as up the curve. Hsf page 1 down as well as up the curve. In kidney it also causes reabsorption which maintains bp in kidney.

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