Physiology 3120 Lecture Notes - Plasma Osmolality, Posterior Pituitary, Diabetes Insipidus

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30 it is a na/ca antiporter, not a symporter (basolateral membrane) Increased fluid uptake = lots of dilute urine: dehydration = low volume of concentrated urine, humans & terrestrial animals can regulate water & sodium balance independently. Intake: from food, fluids, and some from metabolic production; output: through skin and lungs, sweat, feces, and urine: anti-diuretic hormone (adh) Results in increased water reabsorption in collecting duct. Peptide hormone, so it must signal via a cell surface receptor (highly charged, can"t cross membrane) on the basolateral membrane (no blood flow on luminal side, too big to be filtered) Increases camp levels, which inserts more aquaporin ii channels into luminal membrane. Inhibit adh release, which inhibits additional water reabsorption, causing increased urine production. Overall result is dehydration (2) diabetes insipidus. Failure of pituitary to release adh, or by failure of kidney to respond to adh.

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