BIOM20002 Lecture Notes - Lecture 63: Extracellular Fluid, Tubuloglomerular Feedback, Sympathetic Nervous System

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15 Sep 2018
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Driving force of gfr is hydrostatic pressure of glomerular capillaries (55mmhg), which increases with an increase in amount of blood in glomerular capillaries. If you dilate afferent arteriole then you reduce resistance which allows more blood into glomerulus. Inulin is the ideal substance for determining gfr because. It is exogenous (comes from outside the body) Basically we want it to be filtered but nothing else. Filtrate: stuff that comes out of plasma and ends up in kidney. Happens over 24hours (so you know the time). Also need to know conc of inulin in plasma. Using a formula we can work out gfr. Renal clearance: the rate of urinary excretion of a substance, relative to its plasma concentration. If there isn"t much in plasma but a lot in urine then clearance is high. If clearance is low there is probably filtration, metabolism and reabsorption. = u(conc in urine)*v (vol urine over certain time)/p(conc in plasma)

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