BIOM30001 Lecture Notes - Lecture 9: Interleukin 10, Nutrition Transition, Gluconeogenesis

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30001
• Professor: All

Document Summary

Change in incidence of non-communicable disease and metabolic disorder in modern society. Gut microbiota metabolites and how they are sensed by the body. Manipulating the gut microbiota in health and disease. Improved sanitation: development of vaccination and antibiotics. The old friends hypothesis: vital microbial infection, evolution of adaptive immune system, allow selective development of beneficial microbes, training of immune system (is) is driven by broad microbial exposure. Diet hypothesis: nutrition transition, high fat/sugar/salt/refined/processed. Low in fibre: promote development of is. Factors influence gut microbiota: host genetics, maternal transfer, antibiotics and medication. In git microbial composition 2 conditions: symbiosis, microbial metabolites is regulation and homeostasis, dysbiosis, microbial metabolites + virulence factors is dysregulation inflammation. Gut microbiota dysbiosis linked to many disease (inflammatory response: croh(cid:374)"s disease/ibd. Ibs: multiple sclerosis, asthma, type diabetes, cvd, colorectal cancer, neurodegeneration, alzhei(cid:373)er"s disease. Human microbiome is very dynamic in gut. Complexity and number increase as going down the git.