BIOM30001 Lecture Notes - Lecture 18: Ischemia, Radiation Therapy, Leukemia

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30001
• Professor: All

Document Summary

L18 stem cells as cellular therapy and for endogenous repair. Understanding tissue homeostasis and endogenous repair: tissue homeostasis, tissue regeneration, the importance of microenvironment. Understanding the use of stem cells as cellular therapy: haematopoiesis: hscs, bone marrow transplantation for blood disorders, what cells and where from, complications of haemopoietic stem cell transplantation, gene editing for correction of genetic disease. Single cell with ability to regenerate all functional cells within a given tissue. Possess unique properties: rare, quiescent, may be resistant to cytotoxic stress, may be identified by specific genes or surface proteins combinations (immunophenotype, give us ability to identify stem cells. Sc many not required for all types of tissue homeostasis and repair (eg. progenitors) Sc may be required for certain types of tissue regeneration. Liver good for proliferation but heart does not. Specific cells maturing into functional progeny gold standard. Depending on the type of disease or trauma: regeneration: functional cells, fibrosis: stimulated by inflammation, non-functional.