BIOM30001 Lecture Notes - Lecture 4: High-Level Data Link Control, Caucasian Race, Insulin Resistance
16 Oct 2018
School
Department
Course
Professor
Document Summary
Lecture 4 metabolic syndrome: prevention and treatment. Pathophysiology of the metabolic syndrome and insulin resistance. Triglyceride deposition leads to insulin resistance in muscle. Excess visceral fat releases cytokines - these increase insulin resistance and promote lipolysis in fat cells, leading to further ffa secretion. Abdominal obesity + 2 or more of: elevated tg (1. 7 mmol/l) and/or, low hdl-c (<0. 9mmol/l [m]; <1. 3mmol/l[f], hypertension (>130/85mmhg) or treatment, hyperglycaemia (fpg>5. 6mmol/l or igt or diagnosed type 2 diabetes) South asia and chinese (>90cm m; >80cm f) Metabolic syndrome is highly prevalent in many countries. Atherogenic dyslipidaemia classical lipid abnormality in the metabolic syndrome. Clinically de ned as hdl-c <1. 0mmol/l and triglycerides >1. 7mmol/l. Comparison of ldl particles in dyslipiaemic vs normal individuals . Insulin resistance is associated with increased risk of coronary heart disease. Hba1c = used to assess and diagnose diabetes (haemoglobin changed by rbc) Each increment of 20mmhg systolic and 10mmhg diastolic doubles the risk of cvd in the range from 115/75 to.
