BIOM30001 Lecture Notes - Lecture 7: Endothelial Dysfunction, Steatohepatitis, Incretin
13 Sep 2018
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Document Summary
Common condition affecting over 25% of australian adults. Diet and lifestyle intervention to reduce visceral fat, if successful, is effective in preventing. Excess visceral leads to biochemical abnormalities that increase risk of diabetes and cvd diabetes. Drug therapy with metformin can be used to prevent diabetes. Patients are at high risk for cvd and risk factors must be addressed. Statins and anti-hypertensive agents are used to reduce cv risk. Excess visceral fat increases flow of free fatty acids (ffa) to liver and muscle. Triglyceride deposition in muscle leads to insulin resistance. Cytokines increases insulin resistance and promote lipolysis in fat cells, leading to further. When treated with anti-tnf drug, we can see improvement in insulin resistance, but very expensive. Asian visceral obesity starts to accumulate at lower level of bmi: chinese accumulate fat easier then europeans. Relative risk: related to those do not have the disease, not absolute risk: a(cid:374) i(cid:374)dividual"s risk of cv disease relative to the ge(cid:374)eral populatio(cid:374)
