BIOM30001 Lecture Notes - Lecture 31: Solitary Tract, White Adipose Tissue, Vagus Nerve
Document Summary
The peripheral signals involved in body weight regulation. Satiety signals: short term acute signals - turn off a meal/control meal size. Produced as a result of sympathetic and afferent signals. e. g. gastric distension and hormones from git. Cck released from intestine due to break down of carbs and fats. Binds to cck a receptors on vagus nerve which transmits to nucleus tractus solitarius in medulla--> integrates info-->sent to hypothalamus (key area that regulates appetite and energy expenditure) Ghrelin: another short term signal (but not for satiety) - increases appetite when secreted by empty stomach. Adiposity signals: involved in long term control of bodyweight. e. g. insulin and leptin (secreted from white adipose tissue), which circulate at levels proportional to fat mass. Tells brain how much energy stores we have. These hormones actively transported into brain to bind receptors on hypothalamus. Control of body weight is a complex system.
