BIOM30002 Lecture Notes - Lecture 26: Apoptosis, Treatment As Prevention, Cxcl10

• School: University of Melbourne
• Department: Biomedicine
• Course: BIOM30002
• Professor: Helen Cain

Document Summary

Lecture 26 hiv natural history and antiretroviral therapy. Natural history of hiv disease: acute and chronic depletion of cd4 t-cells (cid:894)what happe(cid:374)s to people i(cid:374)fe(cid:272)ted (cid:449)ith hiv a(cid:374)d are(cid:374)"t treated(cid:895) Hiv rapidly spreads throughout body, millions of copies in 6 weeks (clinically see glandular fever-like symptoms) Viral load redu(cid:272)es (cid:449)he(cid:374) i(cid:373)(cid:373)u(cid:374)e respo(cid:374)se ki(cid:272)ks i(cid:374) a(cid:374)d is lo(cid:449)ered to (cid:862)set poi(cid:374)t(cid:863) (cid:894)(cid:448)aria(cid:271)le(cid:895) Ta(cid:455)s sta(cid:271)le o(cid:448)er (cid:1005)(cid:1004) (cid:455)ears, the(cid:374) (cid:449)he(cid:374) i(cid:373)(cid:373)u(cid:374)e (cid:272)a(cid:374)"t (cid:272)o(cid:374)tai(cid:374) it a(cid:374)(cid:455) lo(cid:374)ger, hiv (cid:272)opies sk(cid:455)- rocket leading eventually to death. Massive depletion of cd4+ t cells from git in acute infection (yellow patches of cd4+ t cells disappear) blood cd4+ only part of whole body cd4+ affected. As time infected increases, cd4+ count decreases causing immune deficiency (i. e. aids). Each stage has different/more disorders, infections and autoimmune diseases associated with them. Patie(cid:374)t"s (cid:272)o(cid:374)ditio(cid:374) gets (cid:449)orse the lo(cid:374)ger the(cid:455) are i(cid:374)fe(cid:272)ted (cid:449)ithout treat(cid:373)e(cid:374)t (cid:894)o(cid:271)(cid:448)iousl(cid:455)(cid:895)