MIIM20002 Lecture Notes - Lecture 24: Interdisciplinarity, B Cell, Dendrogram

• School: University of Melbourne
• Department: Microbiology and Immunology
• Course: MIIM20002
• Professor: All

Document Summary

Antiviral therapy (2013) drug classes include nrti (nucleoside reverse transcriptase inhibitors), Nnrti, ntrti (nucleotide reverse transcriptase inhibitor), entry inhibitors (e. g. ccr5 binder), protease inhibitor, integrase inhibitor. Rapid viral turnover (10 billion particles per day) Late haart era patients still have a 10y shorter life expectancy than hiv- controls. Even when treated we do not remove the integrated dna. Ongoing immune activation caused by low virus load+damage to gut leads to non-aids morbidities. Good progress towards 15 million people on antiretroviral treatment by 2015. Treatment as prevention: reduce level of virus in a person, less likely to transmit. Pre-exposure prophylaxis: give to ppl at high risk of hiv. Preventive hiv vaccine-most powerful preventive tool: cornerstone of an integrated prevention program. The pros and cons of vaccine development vs. drug treatments. The natural immune response to hiv does not control the virus, nor protect from (cid:862)superi(cid:374)fe(cid:272)tio(cid:374)(cid:863) (cid:449)ith a differe(cid:374)t strai(cid:374). Mechanisms of protective immune responses against hiv incompletely understood.