BIOS10115 Lecture Notes - Lecture 17: Aids, Hiv-1 Protease, Viral Load
3 Dec 2016
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Prese(cid:374)(cid:272)e of a(cid:374)ti(cid:271)odies to hiv i(cid:374) patie(cid:374)t"s seru(cid:373) Does not detect recent infections (<6 weeks) Also a pcr test that detects viral rna (viral load: used after it is known that antibodies are present, used to monitor effects of treatment. Method to amplify miniscule amounts of dna in the lab. Viral load = how much virus is in the patient: used to detect viral rna. Haart highly active antiretroviral therapy: at least 3 a(cid:374)tiretro(cid:448)iral drugs at o(cid:374)(cid:272)e (cid:894)(cid:862)(cid:272)o(cid:272)ktail(cid:863)(cid:895) 6 categories: nucleoside rt inhibitors, non-nucleoside rt inhibitors, protease inhibitors, fusion inhibitors. Azt azidothymidine nucleoside reverse transcriptase inhibitors (nrtis: reverses the symptoms of hiv but if taken too much can cause other symptoms. Azt la(cid:272)ks 3"oh group (cid:272)hai(cid:374) ter(cid:373)i(cid:374)atio(cid:374) Drug resistance within weeks if given alone. It worked initially but then resistant strands of hiv appeared. Bind to hiv protease: required for viral protein processing and virus maturation. Protease divides the viral material into proteins.
