NEUR30004 Lecture Notes - Lecture 15: Nav1.8, Fibromyalgia, Multiple Sclerosis
11 Aug 2018
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Some of these causes of the vulnerabilities are genetic: There are classes of sodium channels that are only expressed in sensory neurons. Picture on right showing effect of inducing mutation in embryo and showing deficits in normal development of nerves in head of the embryo. In other groups, prdm12 was expressed in nociceptors in progenitors. Get a lot of self-infected injury severe tongue injury by biting. Corneal damage to surface of eye as they are not detecting stimuli. Gain of function mutation involving sodium channels and trypa1 which increase pain sensitivity. Similarly the conduction of signal along the peripheral axon of that sensory neuron is dependent on sodium channels. Peripheral anesthetics target sodium channels block na activity in peripheral axon can cause local anesthetic action. Na involved in central axons in spinal cord where they allow electrical signal to propagate into nerve ending where they can have transmitter release.
