BIO1022 Lecture Notes - Lecture 18: Phagocytosis, Eosinophil, Degranulation
30 May 2018
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BIO1022 – Lecture – 18 – Immunology
- the study of immunity/immune system
- SCID -severe combined immunodeficiency disease
• children that lack ability to generate protective immune responses
• fatal if not treated
- acquired immunodeficiency syndrome - AIDS
• HIV virus kills of the immune system
• increased incidence of disease
- pathogens
• come in many different sizes and shapes
• can invade via different routes
• live in different locations
• have different mechanisms
- the immune system is designed to detect and respond to differences
- how it works
• layers of protection mechanisms
• to stop entry
•
o natural barrier
o
▪ exterior defences
▪ block them out, break them down flush them out
• immediate response
• a specialised and tailored response
- rapid innate vs slower adaptive immunity
• innate
•
o acute rapid response
o not ver specific
o all animals
o same response each time
• adaptive immunity
•
o vertebrates only
o recognition of traits specific to particular pathogens using a cat
array of receptors
o extreme specificity
o specialised responses
o
▪ humoral - antibody
▪ cell mediated
o responses to pathogen improves with exposure
- make up of immune system
• cells
•
o many different cell types
o perform different tasks
o the workforce of the immune system
o originate made from bone marrow
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