BMS1011 Lecture 1: WEEK 9 Lipid Oxidation) & 17 (C5 – CAC)
24 Aug 2018
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Lecture 16 (c4 lipid oxidation) & 17 (c5 cac) Explain the mobilisation and transport of store triacylglycerols: majority of energy needs comes from triacylglycerols (glycerol + 3 fatty acids) fatty acids, muscle utilised fat as preferred energy source. Carry more energy per carbon because are more reduced. Transport lipids absorbed from intestine to adipose, cardiac and skeletal muscle tissue, where the triglyceride component is hydrolysed by lipase to allow release of free fatty acids so it can be readily absorbed by tissues. Glycerol (backbone of lipids) leftover can enter glycolytic pathway. Glycerol phosphorylated, oxidised and isomerised to form d-glyceraldehyde-3-phosphate. D-glyceraldehyde-3-phosphate is a substrate for step 1 of payoff phase. Fatty acid + coa + atp ----------------------------------------- > fatty acyl-coa + amp + 2pi. Fatty acyl-coa + carnitine ------- > fatty acyl-carnitine + coash. Fatty acyl-carnitine + coash ------- > fatty acyl-coa + carnitine. Summarise and demonstrate the importance of stored fat as an energy source.
