CHM1022 Lecture Notes - Lecture 10: Crystal Field Theory, Linkage Isomerism, Theater For The New City
13 Oct 2018
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Document Summary
Linkage isomerism where a single ligand has two or more donor atoms and can attach in more than one way. Exchange of ligands in coordination complex with counter-ions and water molecules. Hydration isomers involve water swapping with a ligand. Ionisation isomers involve exchange of anionic ligands with counter anions. Can occur when both a complex cation and anion are present. This allows for multiple combinations of ligands coordinated to the two metal centres. Geometric isomers cis-isomers are when the identical ligands are adjacent to each other. Trans-isomers are when they are on opposite sites of the metal centre i. e. cisplatin in a highly effective and widely used anticancer drug with formula cis-[ptcl2(nh3)2]. Interestingly trans-[ptcl2(nh3)2] is not active and is toxic! Occur most commonly when there is more than one bidentate ligand in the complex. Just as in organic chemistry, optical isomers are non-superimposable mirror images of each other. Enantiomers are also stereo isomers i. e. mirror images that are non-superimposable.
