IMM2011 Lecture Notes - Lecture 14: Interferon Gamma, Wound Healing, Mast Cell
13 Jul 2018
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Lecture 3 differences between th1 and th2 cells. While th1 cells tend to generate responses against intracellular parasites such as bacteria and viruses, Th2 cells produce immune responses against helminths and other extracellular parasites for atopic disease. Although both activate macrophages they have different function. Th1 cells activate macrophages (m1) to become superb killers of. Th2 cells alternatively activate macrophages (m2) to be so microorganisms specialised in wound repair. Th1- autoimmunity th2- atopic disease- ige : eosinophil and mast cells activated to defend against helminths. Th2 cytokines inhibit th1 differentiation cytokines do they produce. Th1 is important for intracellular pathogen . Th1 then releases ify-y to activate macrophages to becomes efficient killers and promotes antibodies secretion to causes opsonization- Macrophages increases ros, no and proteolytic enzymes- toxic to microbe. Similarity macrophages differentiation from naive t cell. They increased mhc and b7: to actiate other cells can release il 12 to active th1.
