PHY2011 Lecture Notes - Lecture 25: Mitochondrion, Passive Transport, Depolarization

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20 Jun 2018

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Week 9 L3 (T5AL2) -Excitation contraction coupling

Excitation  stimulation by a neuron

Contraction  interaction b/w actin and myosin

Intracellular calcium concentration regulates contraction

Plasma membrane: Sarcolemma

1. Excitable

Transverse tubules

1. Radial invaginations of the sarcolemma

2. Allows APs to reach more microfibrils

3. Also an excitable membrane

4. Run along the z-lines

5. Have voltage sensors (DiHydroPyridine receptors) that communicate with SR

Sarcoplasmic reticulum (SR)

1. Like the ER

2. Intracellular compartment

3. Surrounds each microfibril and t-tubule

4. Uptakes, stores and releases Calcium ions

More calcium in SR than in cytoplasm

-Pumps in against concentration gradient (active transport)

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