PSY2061 Lecture Notes - Lecture 6: Striatum, Series And Parallel Circuits, Pedunculopontine Nucleus
1 Jun 2018
School
Department
Course
Professor
Lecture 6 continued
Function of the cerebellum
Prediction
-of sensory consequences of motor plans
-determine whether movement is being performed correctly
-computes error signal that tells how model can be changed
-explain inability to adapt to changing conditions with damage
Timing
-provides a clock for the timing of different events
-Information of initiation & cessation of movement for different effectors
-explains poor coordination of movement with damage
Basal Ganglia
-Collection of interconnected subcortical nuclei
-Interact closely with cerebral cortex, thalamus & brainstem to guide behaviour
-Multiple, parallel, largely segregated, cortical re-entrant pathways
-Participate in motor, associative & limbic functions
-Dysfunction associated with movement disorders & neuropsychiatric disorders
Basal Ganglia Organisation
•Input (Glutamatergic)
-From layer 5 neurones in cortex to stratum
-From layer 5 neurones in motor cortex to STN (from motor Cortex)!
•Output (GABAergic) !
- from GPi & SNr!
- to: !
1. Thalamic nuclei which projects to frontal cortex!
2. Superior colliculus!
3. pedunculopontine nucleus
Direct Pathway
•Inhibitory connection from stratum to GPi/SNr!
- increased activation reduces tonic inhibitor of thalamus, SC, PPN!
- results in increased facilitation of cortex
Document Summary
Determine whether movement is being performed correctly. Computes error signal that tells how model can be changed. Explain inability to adapt to changing conditions with damage. Provides a clock for the timing of different events. Information of initiation & cessation of movement for different effectors. Explains poor coordination of movement with damage. Interact closely with cerebral cortex, thalamus & brainstem to guide behaviour. Multiple, parallel, largely segregated, cortical re-entrant pathways. Participate in motor, associative & limbic functions. Dysfunction associated with movement disorders & neuropsychiatric disorders. From layer 5 neurones in cortex to stratum. From layer 5 neurones in motor cortex to stn (from motor cortex: output (gabaergic) To: thalamic nuclei which projects to frontal cortex, superior colliculus, pedunculopontine nucleus. Direct pathway: inhibitory connection from stratum to gpi/snr. Increased activation reduces tonic inhibitor of thalamus, sc, ppn. Indirect pathway: inhibitory connection from striatum to gpe, inhibitory connection from gpe to stn, gpi, snr, facilitatory connection from stn to gpi/snr.
