BVB301 Lecture Notes - Lecture 7: Countercurrent Exchange, Ascending Limb Of Loop Of Henle, Autoregulation

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Reabsorption recovery of useful materials that have entered the filtrate: occurs all along the nephron but chiefly (60-70%) in the proximal tubule, as most constituents are filtered out initially, reabsorption plays a greater role than secretion. In mammals >99% of filtered water, salt, amino acids, and glucose are reabsorbed. Secretion: removes waste products and toxins that were not filtered out earlier in the blood, occurs all along the nephron but chiefly in the distal tubule. Proximal tubule: glucose, amino acids, cations (na, ca, h, mg, anions (cl, po, water, urea. Active transport: atp, uses selective transport proteins, can be against concentration gradient. Osmosis: water pulled across the membrane to the higher with the highest solute concentration. Loop of henle: reabsorbs another 15% of the water plus 2/3 of the remaining na and cl. Reabsorption relies on high osmolarity outside of the loop. Countercurrent multiplication: the exchange between fluids moving in opposite directions.

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