BIOL2200 Lecture Notes - Lecture 1: Sphingosine, Signal Transduction, Alkanolamine
Biological membrane: lipids and
membrane proteins lecture 1
Red blood cell (scanning electron micrograph)
Eukaryotes: each organelle has a unique membrane
Membranes are dynamic: HIV particle budding (electron micrograph) membranes arent steady
things… fluid - membrane fusion
Lipids: membrane building blocks one of the main groups found in nature
Insoluble in water
Amphipatic molecules (different properties on each end)
oHydrophobic tail
oHydrophilic head group
Types of lipids 8 major groups of lipids… category code important
Different head groups
Functions of lipids
Structural functions
oMembrane components
oProtein modification
Metabolic functions
oEnergy storage
Other functions
oCellular signalling, including hormones
oEnzyme cofactors
oPigments
o… electron carriers etc
Effects of chain length
Longer the chain length, the less soluable it is (increase hydrophobic character), and higher
melting point
Packing of saturated fatty acids
No solubility because its interacting with the neighboring molecules not the water
Solid structure… saturated fats… no double bonds (make it less straight)
Effects of double bonds mostly cis not trans
Effect of unsaturated fatty acids on packing
Glycerophospholipids alcohol head group
Head groups
All different alcohol: serine is an alcohol bc the OH
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Biological membrane: lipids and membrane proteins lecture 1. Membranes are dynamic: hiv particle budding (electron micrograph) membranes arent steady things fluid - membrane fusion. Lipids: membrane building blocks one of the main groups found in nature. Amphipatic molecules (different properties on each end: hydrophobic tail, hydrophilic head group. Types of lipids 8 major groups of lipids category code important. Longer the chain length, the less soluable it is (increase hydrophobic character), and higher melting point. No solubility because its interacting with the neighboring molecules not the water. Solid structure saturated fats no double bonds (make it less straight) Effects of double bonds mostly cis not trans. All different alcohol: serine is an alcohol bc the oh. Sphingolipids hydrophobic bc its long also connection where it can attach to head group and other fatty acid. N-acyl fatty-acyl derivatives of sphingosine are called ceramides. Most common is cholesterol (also known as sterol)
