BIOM1060 Lecture Notes - Lecture 25: Lymphatic System, Body Composition, Thymus

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8 Jun 2018
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BIOM1060 17/04/2018
LIFECYCLE PHYSIOLOGY
Worldwide trends
- Growing population (increased life expectancy with reduced rates of fertility)
- Rates of illness/death from communicable diseases decreasing, but rates of non-
communicable disease increasing (eg. diabetes, obesity, heart disease)
- Increasing obesity rates and at younger age
- More focus and money spent on treatment rather than intervention/prevention
- Majority of hospitalisations are in very young or elderly
- Men more likely to require medical treatment than women at any age except for during
reproductive years
- Women pregnant with male foetuses more likely to require medical assistance
(miscarriage, preterm birth and pregnancy complications more likely)
Earlier in lifecycle event occurs = larger impact on long term health and disease
Factors influencing physiology
- Genetics
- Environment and lifestyle factors (eg. stress, exercise and nutrition, and exposure to
toxins, pollutants, alcohol and drugs)
o Influence how we are made, how we function and health in later life (aka foetal
programming or DOHAD hypothesis)
Developmental Origins of Health and Disease (DOHAD) hypothesis
- Birth weight as an indicator of exposures during pregnancy and used to calculate risk of
disease in future life (only a estimation - actual cause of disease is multifactorial)
- Reduced or very large birth weight = increased risk of disease in future life
First 1000 days of life
- First 1000 days = 280 days of pregnancy + 730 days
- Strategy of prioritising early life interventions in order to decrease disease in later life
o Found to be optimal window for care
- Presented by WHO as an effective way to reduce burden of disease in society
Improving long-term health during pre-conception and early pregnancy
- Have children at optimal age (20-35yrs)
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Document Summary

Growing population (increased life expectancy with reduced rates of fertility) Rates of illness/death from communicable diseases decreasing, but rates of non- communicable disease increasing (eg. diabetes, obesity, heart disease) More focus and money spent on treatment rather than intervention/prevention. Majority of hospitalisations are in very young or elderly. Men more likely to require medical treatment than women at any age except for during reproductive years. Women pregnant with male foetuses more likely to require medical assistance (miscarriage, preterm birth and pregnancy complications more likely) Earlier in lifecycle event occurs = larger impact on long term health and disease. Environment and lifestyle factors (eg. stress, exercise and nutrition, and exposure to toxins, pollutants, alcohol and drugs: influence how we are made, how we function and health in later life (aka foetal programming or dohad hypothesis) Developmental origins of health and disease (dohad) hypothesis.

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