MEDI7212 Lecture Notes - Lecture 60: Cyclophosphamide, Razor Strop, Medical Emergency
Document Summary
Definition: chronic, benign autoimmune disease associated with lymphoid infiltration of exocrine glands, particularly salivary and lacrimal glands, leading to secretory gland dysfunction and severe sicca symptoms. Clinical manifestations: types, primary - usually f, 40-50yo onset. Secondary - concurrent ra or another ct disease (sle, systemic sclerosis: glandular features. Salivary gland enlargement and calculus formation: dry eyes, dry mouth, dry cough and hoarse voice (trachea, rarely, loss of gi exocrine function causes pancreatitis and atrophic gastritis. Lymphoid infiltration of kidney, lung, skin, muscle, stomach and liver. Lymphoid infiltration in minor salivary glands on lip biopsy for diagnosis in absence of antibodies ro and la. Management: dry eyes & dry mouth via dry mucosal membranes -> ulceration & scarring, see introduction. Definition: an uncommon condition whereby excessive collagen deposition leads to fibrosis or thickening of the skin. Localised form limited to the skin - morphoea.
