MEDI7212 Lecture Notes - Lecture 77: Heparan Sulfate, Nephron, Bone
Document Summary
Incontinence: confusion, definition, cellular and physiological deterioration leading to vulnerability to disease and death, biological theories. Rate of living ("live fast, die young": ageing is a loss of redundancy -> lose higher order functions first (falls, divided thinking, bowels, physiological changes with ageing. Increase: arterial wall thickness, resting bp and tpr, endothelial permeability, decrease, arterial compliance, barocepter sensitivity - impaired orthostasis (eg worse reaction to dehydration, bp medication, endothelial no release (endothelial dysfunction) Physiological functional capacity: decrease, aerobic performance, cv responsiveness, autonomic homeostasis. Gas exchange decrease: pulmonary capillary blood volume, distensibility of pulmonary arterial vasculature. Loss of alveoli and increased size of alveoli (coalesce together; less functioning) Increase: residual volume (air remaining in lungs, p(a-a)o2 = related to vq mismatch. Ventilatory control: decrease, responsiveness to hypoxia and hypercapnea, protective reflexes in the airways. Liver size and blood flow: pancreatic mass and enzyme reserve (t2dm risk increased, gut contractility/ slowed gastric emptying (more likely to vomit)
