MICR3002 Lecture Notes - Lecture 33: Sv40, Gardasil, Globulin

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10 Aug 2018
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Immunisation with cowpox induces antibodies against antigens (cid:1)(cid:1) cowpox antibodies bind & neutralise smallpox virus (cid:18)(cid:8)(cid:19)(cid:5)(cid:20)(cid:8)(cid:5)(cid:21)(cid:3)(cid:22)(cid:22)(cid:12)(cid:15)(cid:7)(cid:10)(cid:5)(cid:19)(cid:8)(cid:6)(cid:24)(cid:17)(cid:5) (cid:1)(cid:1) vaccines work by stimulating a protective immune response by mimicking infection: (cid:1)(cid:1) use attenuated virus to induce adaptive immune response. Immunity to reinfection usually life+long (cid:1)(cid:1) mostly igg/iga neutralisation (cid:1)(cid:1) passive (cid:1)(cid:1) Induces life+long immunity (cid:1)(cid:2)(cid:3)(cid:4)(cid:5)(cid:3)(cid:6)(cid:7)(cid:5)(cid:4)(cid:2)(cid:7)(cid:5)(cid:20)(cid:12)(cid:11)(cid:11)(cid:7)(cid:6)(cid:7)(cid:15)(cid:4)(cid:5)(cid:4)(cid:26)(cid:16)(cid:7)(cid:10)(cid:5)(cid:8)(cid:11)(cid:5)(cid:21)(cid:3)(cid:22)(cid:22)(cid:12)(cid:15)(cid:7)(cid:10)(cid:17)(cid:5) (cid:1)(cid:1) there are 3 basic types of vaccines that can be used to provide immunity to viruses: (cid:1)(cid:1) sub+unit vaccines (cid:1)(cid:1) inactivated vaccines (cid:1)(cid:1) live virus vaccines (cid:1)(cid:2)(cid:3)(cid:4)(cid:5)(cid:3)(cid:6)(cid:7)(cid:5)(cid:12)(cid:15)(cid:3)(cid:22)(cid:4)(cid:12)(cid:21)(cid:3)(cid:4)(cid:7)(cid:20)(cid:5)(cid:21)(cid:3)(cid:22)(cid:22)(cid:12)(cid:15)(cid:7)(cid:10)(cid:17)(cid:5) (cid:1)(cid:1) Inactivated vaccines are vaccines which use viruses which have been denatured: (cid:1)(cid:1) method of production (cid:1)(cid:1) denaturation of living virus by exposure to denaturing agent (cid:1)(cid:1) eg. Induce long+lived, appropriate immunity (cid:1)(cid:1) disadvantages (cid:1)(cid:1) unstable (cid:1)(cid:1) biochemically (live virus) (cid:1)(cid:1) genetically (can revert to virulence) (cid:1)(cid:1) Infant shedding of polio virus (cid:1)(cid:1) not possible to produce in all cases (cid:1)(cid:1) contamination is possible (sv40) (cid:1)(cid:1) Inappropriate vaccination may lead to disease (cid:1)(cid:1) eg.

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