MICR3002 Lecture Notes - Lecture 2: Reoviridae, Membrane Fusion Protein, Endosome
Document Summary
To initiate replication, must adhere to host cell plasma membrane: mediated by binding to a cell receptor, contact can also be made through other molecules though. Infection in particular cell subsets: susceptible (appropriate receptor for virus) and permissive (allows virus to enter and replicate, tropism (specificity for cell types) Terminally modified sugars (such as sialic acid) Components of the extracellular matrix (eg. glycosaminoglycans sticky and allow for attachment) Receptor molecules: only of differentiated cells, allows for restricted tropism, examples: hepatitis b (liver cells), hiv (cd4 t cells and macrophages) More than one cell receptor: affects different tissues, example: rabies (acetylcholine receptor and cd56) More than one virus attachment protein: several may be needed for different attachment sites, example: herpes (gb and gc gag binding, gd secondary receptor, nectin-1) Same receptor: multiple viruses using the same receptor for attachment, examples: hiv and hsv7 (cd4), adenovirus and coxsackle b (car)
