PHRM3011 Lecture Notes - Lecture 11: Hyperlipidemia, Lipoprotein, Naproxen
Document Summary
75mg, 100mg, 150mg daily increased bleeding and same efficacy with 300mg due to cox2 inhibition. All pts. who have had a pci (limited duration) Not for pts. who have only had a stroke. Cholesterol lowering drugs statins pravastatin, simvastatin, atorvastatin, rosuvastatin fibrates. Ezeimibe linear relationship between ldl reduction and cv events. All pts. with stemi, nstemi or stable angina. Bisoprolol very b1 selective, 29113 (pbs, only for heart failure) Carvedilol - 29113 (heart failure), excellent efficacy, non-selective (b1, b2, a) Propranolol non-selective (b1,b2), bronchoconstriction, don"t use. Best evidence for use in mi and heart failure. Not always given in mi without hf. 36: depression can cause mis (depression = increased adrenaline and noradrenaline, therefore can increase risk of ha) Verapamil/diltiazem: good if cant use bb, avoid in hf. Amitriptyline (tca: mi and rhythm disturbances. Nsaid"s/cox2 inhibitors: used naproxen if must more cox 1 selective. Both increased tris and cholesterol = mixed hyperlipidaemia. Lipoproteins (ldl) from liver to cells (bad)
