PHRM4011 Lecture Notes - Lecture 2: Asthma, Streptomycin, Heart Failure
Document Summary
Digoxin/amiodarone avoid as 1st line for af, ppis bone loss and increased fractures. B12 deficiency: thiazides exacerbate gout, nsaid selective vs nonselective vs paracetamol same efficacy for oa. High gi risk ppi + naproxen (lowest cvd/gi risk) Se asthma, na retention water retention hypertension, gord, bleeding: aminoglycoside streptomycin mainly used for tb. Aminoglycoside se acute renal failure, tinnitus: hypertension targets (<120/80 = normal, >140/90 = hypertension) Maximise ca channel blocker/sartan/prils, exercise, low sodium diet, limit drinking, check for postural hypotension: diabetes target. If elderly, can be more lenient hba1c>7. 5. If diabetes for more than 10 years, more risk of hypos than hyper therefore more lenient: ldl target. 2 only if at risk of cvd: ca channel blockers amlodipine. Can stop immediately, no need to wean: metformin normal crcl 3g d or 2g controlled release d. Macro/microvascular benefits reduces risk of dying. Check blood sugar levels, hba1c in 3 months. Se bleeding, hyponatraemia, suicidal thoughts, nausea, insomnia.
