MEDI211 Lecture 10: Endocrine 4
6 Aug 2018
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Document Summary
Diabetes mellitus: diabetes (going through), mellitus ( honey/sweet", endocrine/metabolic disorder = impaired insulin availability and effects. Impaired release: absolute deficiency, defective/insufficient insulin receptors. Insulin destroyed prior to action: type i and ii. Short-term consequences of untreated t1dm: diabetic ketoacidosis: t1 diabetics prone to ketoacidosis, decreased insulin = increased glucagon + increased epinephrine. Insulin inhibits hormone sensitive lipase (hsl): inhibits lipolysis, epinephrine opposite. Insulin replacement therapy: exogenous insulin replacement therapy: Insulin injections control, not cure t1dm: cant replicate normal close relationship between [blood glucose] and. In non diabetic individuals, intricate pulsatile insulin release: close glucose:insulin relationship (proportional control) Insulin induced hypoglycaemia and counter regulation in type 1 diabetes: redundancy, multiple systems dedicated to preservation of important responses, minimises impact of acute removal of one regulatory signal. Transplantation options: pancreas transplant (can be with kidney, hyperglycaemia damages kidney, original pancreas remains as exocrine function still working, pancreatic islet cell transplant.
