MEDI211 Lecture Notes - Lecture 7: Secondary Sex Characteristic, Eli Lilly And Company, Insulin Receptor
6 Aug 2018
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Many aas = protein: early protein bind to rer, signal sequence cleaved, ribosome unit continues to read mrna until completion, ribosome dissociates from mrna, protein now synthesised. Processing of peptide hormones: when a peptide hormone is synthesised from its constituent amino acid it is a. Preprophormone (inactive: ar the rer, the signal peptide is cleaved and the polypeptide becomes a. Classes of membrane receptors: three main types of receptors for peptide hormones, ligand gated ion channels, multiple subunits transmembrane protein, channel opens and closes. G protein coupled receptors: large receptor family, multiple types, different g protein subunits, e. g. = activated ac vs gai = inhibitory = inhibits ac: different subtypes: one hormone can interact with numerous downstream pathways, e. g. dopamine binds to. Tyrosine kinase receptors: phosphorylate tyrosine residues on themselves and/or other proteins, e. g. insulin receptor. Insulin binding changes conformation of alpha/beta chains: activates tyrosine kinase (on beta chains, an enzyme, transfers phosphate group to another signalling component (e. g. irs)
