AMME1362 Lecture Notes - Lecture 4: Frameshift Mutation, Germline Mutation, Mutation
17 Oct 2018
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Document Summary
After transcription, a process called splicing occurs, which involves the removal of introns, or non- coding region of the rna, leaving the exons, or the coding regions. Insertion or deletion of one or more nucleotide pairs in the dna of a gene. Germline mutation occurred in a patients forebears, passed on in sperm or ovum and are present in all cells. The introduction of normal genes into cells in place of missing or defective ones to change gene expression and correct genetic disorders. *note: only 1 gene therapy product approved by the fda to date. Non specific, 1st line of barrier/ defense mechanism upon the introduction of an antigen in the body. Include skin, chemicals in blood, phagocytes (type of wbc/leukocyte), etc. Constitutes of humoral defensive response (performed by b lymphocytes; type of leukocytes/wbc and cell mediated defense response performed by t lymphocytes.
