AVBS1003 Lecture Notes - Lecture 16: Devil Facial Tumour Disease, Transplant Rejection, Mhc Class I

• School: University of Sydney
• Department: Animal and Veterinary Bioscience
• Course: AVBS1003
• Professor: Claire Wade

Document Summary

Lecture 16 : saving the tasmanian devil from extinction. Young weigh 0. 2g, den at 100 days old, independent at 9 months. Lesions around the face & mouth - metastasise. Very limited evidence of natural recovery or immunity. It arose from a schwann cell in a female devil. Immune tissues and cells similar to other mammals. B & t lymphocyte activation and proliferation. Hypothesis 1 : tumour seen as self" because devils lack diversity at mhc genes. Hypothesis 2 : tumour evades the immune system by down-regulating mhc expression. Key region of genome involved in response against. Mhc i presents antigens to cytotoxic cells. Hypothesis 1 : mhc diversity and skin grafts. Donor and recipient need to be matched at mhc genes for organ transplantation. Cheetah immune system doesn"t recognise mhc differences between unrelated individuals. Mhc diversity is critically low devils share the same mhc type as the tumour.