BIOL1006 Lecture Notes - Lecture 15: Allele Frequency, Assortative Mating, Genotype Frequency

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Lecture 15: Mechanisms of evolutionary change
Mutation
- Raw material of evolutionary change
- By definition, a mutation will alter allele frequency in a population (A a, a A, or A
B)
- Does not have much effect on allele frequencies, especially in large populations.
Differences between populations are not usually due to mutation frequency.
Assortative mating
Non- random mating
- Like mates with like
- May distort H-W equilibrium
- Produces excess homozygous genotypes
- Does not in itself change allele frequencies
Migration/gene flow
- May introduce new alleles or change existing allele frequencies
Effect depends on:
- Differences in allele frequencies between source and destination
- Number of migrants
Evolution by migration example
An initial population of 100 individuals has allele frequencies of p = 0.5 and q = 0.5 at a locus
with 2 alleles (A and a).
- What are the initial genotypic frequencies (assuming HWE)?
- If the population is invaded by 81 AA, 18 Aa and 1 aa migrants from another population,
what are the new allele frequencies?
- Will migration change allele frequencies?
Genetic drift
- Changes in allele frequency caused by chance
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Document Summary

By definition, a mutation will alter allele frequency in a population (a a, a a, or a. Does not have much effect on allele frequencies, especially in large populations. Differences between populations are not usually due to mutation frequency. Does not in itself change allele frequencies. May introduce new alleles or change existing allele frequencies. Differences in allele frequencies between source and destination. An initial population of 100 individuals has allele frequencies of p = 0. 5 and q = 0. 5 at a locus with 2 alleles (a and a). Changes in allele frequency caused by chance. Endangered species and loss of genetic diversity. Fixation or loss of alleles results in homozygosity e. g. bush rats from south australia. Simulates the effect of initial population sizes and allele frequencies on genetic drift. Non- random survival of alleles in a population. Different genotypes differ in their fitness and make disproportionate contributions to the gene pool.

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