EXSS2021 Lecture Notes - Lecture 10: Insulin Resistance, Portal Venous System, Fatty Acid-Binding Protein
22 Aug 2018
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Document Summary
Intramuscular triacylglycerol (imtg): stored adjacent to mitochondria, total active muscle mass = ~300g tg, found in small droplets, type i > type ii, endurance trained > non-endurance trained, store more intramuscular tg with et, dietary effects. After fa are oxidized by the tissues, glycerol returns to the liver & can be used to form new tg or enter glycolytic or gluconeogenic pathways. Fa are oxidised by the tissues including muscle. Transport of nefa to muscle: processes which limit muscle fa uptake, membranes of vascular endothelial cells, interstitial space between vascular endothelium and muscle cell, muscle (sarcolemma) membrane: Initially thought to be passive diffusion: now known to use transport proteins, fatty acid binding proteins (fabp, fabp > type i fibres, fabp > et, prior to entering the mitochondria, fa are activated fatty-acyl coa. Intralipid infusion (food through vein; purify glucose/intralipid etc. )
