PHAR3816 Lecture Notes - Lecture 10: Deep Vein Thrombosis, Inflammatory Bowel Disease, Chronic Kidney Disease
22 Jul 2018
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Document Summary
In australia, 30 000 people are hospitalized each year as a consequence of vte, with approximately 2000 deaths. Haemostasis is the normal physiological response that prevents significant blood loss following vascular injury. The process depends on an intricate series of events involving platelets, other cells and the activation of specific blood proteins, known as coagulation factors. When blood vessel injury occurs, physiological haemostasis is triggered and the coagulation process occurs. Haemostasis serves to maintain the integrity of the circulatory system; however the process can become imbalanced, leading to significant morbidity and mortality. Extrinsic: release of products (tissue factor) due to damage of blood vessel wall. Both pathways lead to production of factor xa, which converts prothrombin to thrombin; fibrinogen to fibrin and fibrin forms the clot. Venous thromboembolism encompasses deep vein thrombosis (dvt) and pulmonary embolism. Thrombosis: process involved in the formation of a fibrin blood clot (platelets and clotting factors also contribute to clot formation)
