VETS1032 Lecture Notes - Lecture 23: Carbamoyl Phosphate Synthetase, Carbamoyl Phosphate, Oxidative Deamination
24 Jul 2018
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Document Summary
The urea cycle aims to convert ammonia to urea as urea can easily be removed from the body. Parts of the urea cycle are in the cytoplasm and mitochondria. It begins in the mitochondria, where the ammonium ion and carbon dioxide produce the intermediate molecule - carbamoyl phosphate. This reaction requires 2 atp molecules and is catalyzed by carbamoyl phosphate synthase. Carbamoyl phosphate combines with ornithine (aa) through an condensation reaction which leads to citrilline. The citrilline is then transported to the cytoplasm and combines with aspartate and leads to the formation of arginosuccinate. This reaction is cataylsed by arginosuccinate synthase and uses one atp molecule. Arginosuccinase lyses to forms two molecules- fumerate and arginine then the production of urea and urea is then liberated. The urea cycle: series of reaction, ureotelic organism to excrete urea, ureotelic organism excrete uric acid (bird and reptile, ammonetelic organism excrete ammonium (aquatic animal)
