300884 Lecture Notes - Lecture 13: Muscarinic Antagonist, Major Depressive Disorder, Fluphenazine
27 Feb 2019
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Document Summary
Psychosis: medical condition characterised by highly distorted contact with reality with a lack of insight with thought and judgement impairment. Schizophrenia: drugs are used in psychotic states known as. Schizophrenia dopamine theory: excess dopamine in the. Glutamate theory: reduced function of glutamate on. Antipsychotic drugs block dopaminergic receptors in the mesolimbic system. Unwanted effects of a. d: endocrine effects, weight gain, sedation, antiadrenergic. Parkinson-like syndrome controlled with muscarinic antagonist to neuroleptic treatment. Muscarinic antagonist unwanted effects: dry mouth, blurred vision, constipation. 75% of all cases & is linked to distressing life situations. Endogenous unipolar shows no known cause however genetic factors are vital. Oscillation between depression and mania where every episode lasts 3-6 months and episodes may be separated by normal moods: strong hereditary link. Monoamine theory of depression: due to deficient monoamine. Pharmacological evidence: current antidepressant drugs facilitate and enhance monoaminergic transmission. Selective serotonin reuptake inhibitors (ssri) have high. Tetracyclic antidepressants/ noradrenergic and specific serotoninergic antidepressants.
