IMED1004 Lecture 59: 11.1 Apoptosis I, II, III
30 Nov 2018
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Document Summary
Cell control and apoptosis i, ii, iii: consider how normal cells respond to internal and external homeostatic cues. Normal cell proliferation is modulated by regulation of the cell cycle. Apoptosis eliminated damaged cells (damaged organelles, damaged dna, not needed in the body, infected by virus) & cells needed only temporarily during development: controlled webbing between fingers eliminated but the arm wasn"t apoptosed. Later: the accumulation of mutations in cancer cells allows them to escape apoptosis & proliferation controls: necrosis not responding to the signals to stop proliferation, hence continues to divide. Regulate tissue masses and cells- harmony with other systems in the body and internal environment. Some cell loss is accidental, other cell loss is through programmed cell death (apoptosis: cell is abnormal in some way e. g. dividing too rapidly. Precise control during development & growth: crucial- determines size and shape of organs/tissues, right number of cells in the right position, developing and in adults.
