IMED2001 Lecture Notes - Lecture 3: Innate Immune System, C3B, Complement System
26 Mar 2020
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Document Summary
Heavily related to the adaptive response as antibodies are important in its activation. Bacterial lysis, macrophages, other cells feed up into it. Job is to enhance bacterial microbial destruction through 2 major pathways (lysis, and phagocytosis via opsonisation) Important in inflammation in tissue and in the blood system. Immune defence involves recognition of pathogens followed by their destruction: Complement system of plasma proteins (circulating in the body) mark pathogens for destruction this is the first. Wave of response in barrier type responses: soluble proteins constitutively made in the liver, present in blood, lymph, extracellular fluids. Complement coats surface of bacteria (opsonisation) and extracellular viral particles enhancing phagocytosis. Without complement coating many organism can resist phagocytosis . Capsule (hiding antigenic surface/key features on their surface- hence complement can"t necessarily bind either) Many in the blood and plasma and inactivate forms (zymogens: requires activation. Results from covalent attachment of c3b to a pathogen"s surface. Many complement components are proteolytic enzymes or proteases.
