IMED3001 Lecture Notes - Lecture 3: Aortic Valve, Mitral Valve, Heart Valve
26 Mar 2020
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Phases of cardiac cycle: ventricular diastole (filling) Passively: atrial systole, priming pump, approx 25, working in an open system, contracting with an open system therefore unable to generate enough pressure- its just to squeeze a little bit more blood, ventricular systole. Myocyte: sarcolemma extensions of the plasma membrane are t tubules and transfer the ap to the middle of the cell into the sr. If cardiac is contracted for a long period of time, dead it is physically stopping it from going under wave summation or tightness of muscle. Contraction of cardiac muscle: contraction via voltage gated ca channels, relaxation when l type channels close, ca pump in. Sr as well as na/ca exchanger in sarcolemma to remove the ca from cytosol: difference in how we couple ca and na, dhpr- physically opens ryr2. Refractory period: this mechanism stops muscle from going into. Intrinsic conduction system: endemic initiation within the heart, all a cells connected by gap junctions, same for.
