IMED3004 Lecture Notes - Lecture 2: Stratum Basale, Nociceptor, Vasomotor
1 Nov 2020
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If we want to conserve heat we constrict the vessels to keep warmth in the body. Your skin regenerates + repairs itself: high cell turnover ~10-30 days (epidermis) Epidermal stem cells (stratum basale) proliferate, differentiate and slowly migrate and die (25-45 days): other stem cells form appendages (not epidermis) Regeneration is layer dependent: both layers regenerate, but process differs. First-degree burn: involves only epidermis: redness, slight oedema, and pain, heals in days. Your skin is sensational!: light touch, tactile (meissner"s) corpuscle rapidly adapting mechansensor, altered touch, spatial characteristics, tactile (merkel"s) disks. Continuous light touch (steady state info: heavy touch pressure! Lamellar (pacinian) corpuscle: rapidly adapting mechanosensor, deep pressure, vibration, bulbous (ruffini"s) corpuscle. Slowly adapting mechanosensor: heavy touch, stretch, gives us proprioception. Provides the rate-limiting step in vitamin" d synthesis: vitamin d is not a vitamin. Transient receptor potential (trp) channels: temperature-sensitive ion channels, excitatory na+/ca2+ channels.
