IMED3004 Lecture Notes - Lecture 7: Dipeptidyl Peptidase-4, Gluconeogenesis, Liraglutide
1 Nov 2020
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Document Summary
Type ii diabetes: complex interplay between genetic (>120 genes) & environmental factors strongly associated with obesity. 90-95% adult dm, in children too long asymptomatic phase still develop complications. Treatment for t2d: lower blood glucose levels prevents microvascular complications treatment should be individualised. Insulin added in (maintain on at least one oral drug) if/when needed (majority eventually will) Reduction of cardiovascular risk treat ht treat dyslipidaemia if albuminuric, consider ace inhibitors. Exercise: weight loss - 5-10, monitor control by. Stop smoking! checking for glycosuria is all that"s needed. Pharmacokinetics: excreted unchanged in urine drug interactions - clearance with other renally excreted drugs. Side effects & cautions: gi - transient anorexia & diarrhoea (30%), helps weight, vitamin b12 deficiency ( absorption?) Screen your patients lactic acidosis - extremely rare (rf + cardiac/respiratory disease) C/i in renal failure (egfr <30) or severe hepatic impairment. Is the drug of first choice for t11d.
