IMED3004 Lecture Notes - Lecture 11: Goitre, Immunohistochemistry, Hypoglycemia
1 Nov 2020
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Document Summary
Paired glands, anterior and superior to renal upper pole. Produces corticoid hormones under control of endocrine system. Produces catecholamines (adrenaline, noradrenaline and dopamine) under control of autonomic nervous system. Produces three groups of steroid hormones derived from cholesterol production stimulated by acth. Action of corticoid hormones: mineralocorticoids, maintain normal intravascular volume and ph by retaining sodium and water and eliminating potassium and hydrogen ions, dependent on renin-angiotensin system: Renin: released in response to low blood pressure in afferent arterioles, elevated levels of circulating catecholamines or low: na levels in distal convoluted tubules, angiotensin ii: induces vasoconstriction stimulates aldosterone secretion increase tubular na resorption. Glucocorticoids: under pituitary control (acth), normal morning peak of release, metabolic regulation (protein, carbohydrate, fat) Redistribution of fat (complex actions: modulation of innate and adaptive immune response, also weak mineralocorticoid action. Syndromes of hyperadrenalism caused by overproduction of 3 major hormones of adrenal cortex: cushing syndrome (hypercortisolism, conn syndrome (hyperaldosteronism, adrenogenital or virilising syndrome (androgens)
