IMED3004 Lecture Notes - Lecture 3: Zona Reticularis, Insulin-Like Growth Factor 1, Adenylyl Cyclase
1 Nov 2020
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Endocrine control systems: monitors internal and external environments and regulates appropriate adaptive changes. Secreted into the circulation: multiple hormone systems regulate most functions of the body: e. g. metabolism, growth, development, water & electrolyte balance. Behaviour: non-endocrine tissue can also secrete hormones: e. g. kidneys epo. Skeletal muscle myokines (il- 6, cntf, igf-1: adipose tissue leptin (controls feeding) Humoral: respond to changing levels of ions or nutrients in the blood (measures some parameter in the lumen of gut: neural: stimulation by nerves. Hormonal: stimulation received from other hormone fine tuned and adaptive) These components differ based on the biochemistry of the hormone molecule. Protein/peptide hormones hydrophilic tyrosine-derived hormones really small variable. Vast majority of hormones because its made from genome. Stored in secretory granules or vesicles exocytosis release. Hydrophilic bind cell surface receptor & activate intracellular signalling paths. Rapid acting, short lived: act quickly (minutes of release). Include: cortisol, aldosterone, testosterone and progesterone. (takes huge amount of energy to make)
